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Gm and Inv allotypes in a Gypsy sample.

M Daveau, L Rivat, A Langaney

    Human Heredity
    |January 1, 1975
    PubMed
    Summary
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    This study analyzed Gm and Inv immunoglobulin allotypes in 226 Gypsies, revealing diverse phenotypes and common haplotypes. The Gypsy population showed low frequencies for Inv(1) and Inv(2) markers.

    Area of Science:

    • Immunogenetics
    • Population Genetics
    • Anthropology

    Background:

    • Immunoglobulin allotypes (Gm and Inv) are polymorphic genetic markers used to study human populations.
    • Previous studies have characterized Gm and Inv allotypes in various ethnic groups, but data for Gypsy populations are limited.

    Purpose of the Study:

    • To investigate the Gm and Inv allotype profiles in a Gypsy population.
    • To identify common Gm haplotypes and compare them with those found in other major ethnic groups.
    • To determine the frequency of Inv(1) and Inv(2) in this population.

    Main Methods:

    • Serum samples from 226 individuals of Gypsy origin were collected.
    • Gm and Inv allotypes were determined using serological methods.
    • Phenotype and haplotype frequencies were calculated and compared with existing data.

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    Main Results:

    • A wide array of Gm phenotypes were observed, with Gm(4,5,8,10,11,14,17,23,25) and Gm(1,2,4,5,8,10,11,14,17,21,23,25) being the most frequent.
    • Nine common haplotypes were identified, explaining most of the observed Gm phenotypes.
    • Specific Gm haplotypes showed affinities to those prevalent in Caucasoid, Mongoloid, and Negroid populations.
    • A very low frequency of Inv(1) and Inv(2) was found in the studied Gypsy population.

    Conclusions:

    • The Gm and Inv allotype distribution in Gypsies reflects a complex genetic heritage.
    • The identified Gm haplotypes suggest admixture with various ancestral populations.
    • The low Inv(1) and Inv(2) frequencies warrant further investigation into the genetic markers of this population.