Diabetogenic effect of oral diuretics in asymptomatic diabetes

Ten patients with asymptomatic diabetes were given 40 mg furosemide, or 50 mg dihydrochlorothiazide, or 50 mg ethacrynic acid alternatively each for a week. Glucose tolerance tests were performed weekly. There was no significant change in the G.T.T. values during the test period. The result support the view that the "diabetogenic" effect of thiazides can not consitute a contraindication to the use of these compounds, as diuretics and the drugs under review probably do not differ significantly in this respect.