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Hypertonic balanced sodium solution in burn shock.

C L Fox

    International Surgery
    |June 11, 1975
    PubMed
    Summary
    This summary is machine-generated.

    The optimal sodium solution for burn resuscitation involves approximately 22.5 mEq/kg body weight. A solution with 225 mEq sodium and 160 mEq chloride per liter, mimicking plasma

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    Area of Science:

    • Biomedical Research
    • Emergency Medicine
    • Fluid Resuscitation

    Background:

    • Thermal injuries, or burns, can be fatal.
    • Effective resuscitation is critical for survival after severe burns.
    • Identifying optimal fluid compositions is essential for burn care.

    Purpose of the Study:

    • To determine the most effective sodium solution for resuscitation following thermal injury.
    • To evaluate the impact of different sodium concentrations and doses on survival rates.
    • To identify the ideal sodium-to-chloride ratio for burn resuscitation.

    Main Methods:

    • Standardized scald burns were inflicted on mice.
    • Various sodium chloride solutions (75-300 mEq/L) were administered at different doses.

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  • Effectiveness was assessed by 24-hour mortality, body weight changes, and electrolyte levels.

    • Main Results:

    • A broad range of sodium solutions proved effective.
    • Optimal sodium intake was approximately 22.5 mEq/kg body weight.
    • Solutions with 225 mEq sodium/L and a sodium-to-chloride ratio closer to plasma improved survival.

    Conclusions:

    • The optimal sodium concentration for burn resuscitation is approximately 225 mEq/L.
    • Fluid resuscitation efficacy is enhanced when the sodium-to-chloride ratio approximates that of blood plasma.
    • Hypotonic solutions demonstrated reduced effectiveness in burn resuscitation.