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Abstract:
(1) A penciclovir skin cream has been approved in France for local treatment of herpes simplex labialis. (2) The clinical file is limited to a single trial versus the excipient. This double-blind trial showed that, even when started immediately after the first manifestations occur, penciclovir cream failed to prevent the emergence of skin lesions. The only effect was a reduction in the duration of the lesions and associated pain by a few hours. In the absence of any specific assessment, there is no evidence that penciclovir improves overall patient satisfaction. (3) Penciclovir has not been compared with aciclovir skin cream.