Headache due to antimigraine 5HT1 receptor agonists

(1) Like other analgesics and antimigraine drugs, the 5HT1 receptor agonists, or triptans, can cause a self-sustaining headache syndrome. (2) Headache due to 5HT1 receptor agonists should be suspected when a patient presents with an increased frequency of migraine or non migraine headache associated with daily intake of such drugs. Withdrawal usually leads to the disappearance of those headaches that are due to the drug, or at least a reduction in their frequency.