Related Experiment Videos
Agonist concentration gradients as a generalizable regulatory implementation strategy
1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
Critical Reviews in Toxicology
|August 16, 2001
Abstract:
This article proposes a general mechanism by which biphasic dose-response relationships occur in pharmacological and toxicological experimental systems. Such biphasic responses are mediated via a strategy of differential binding to stimulatory and inhibitory receptor subtypes based on agonist concentrations. Such a strategy is widely seen in pharmacological systems and has been demonstrated in toxicological-related biphasic dose responses in which the treatment altered levels of endogenous agonists.