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Published on: December 26, 2011
Prostaglandins: biphasic dose responses
1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
Abstract:
Biphasic dose responses induced by prostaglandins are documented and assessed with respect to quantitative features of their dose-response functions, mechanistic foundation, and biological generalizability. Biphasic responses were seen for multiple endpoints, including DNA synthesis, neutrophil migration, corticosterone production, fibroblast proliferation, and other parameters. In addition, numerous nonsteroidal antiinflammatory agents and other drugs alter prostaglandin concentrations and/or transport in a biphasic dose- response manner. These findings have considerable implications for the understanding of basic biological regulatory processes as well as clinical practices.
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