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Androgens: biphasic dose responses
1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
Critical Reviews in Toxicology
|August 16, 2001
Abstract:
Testosterone was reported to affect a variety of reproductive endpoints. More notable were the effects of dihydrotestosterone on cell proliferation in the prostate cancer cell model LNCaP and Sertoli cell function. Testosterone production was also biphasically affected by prolactin that was administered to adult testicular cells in vitro.