Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opiates: biphasic dose responses.

E J Calabrese1

  • 1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu

Critical Reviews in Toxicology
|August 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy.

Mechanisms of ageing and development·2022
Same author

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose.

Human & experimental toxicology·2019
Same author

Funding trends in hormetic research.

Human & experimental toxicology·2019
Same author

Originator of the hormesis concept: Rudolf Virchow or Hugo Schulz.

Human & experimental toxicology·2017
Same author

Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders.

Journal of neuroscience research·2016
Same author

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Brain research·2016

Opiate drugs often show biphasic responses across various animal models and biological functions. While maximum stimulatory effects are similar, the effective dose ranges vary significantly, requiring mechanistic investigation.

Area of Science:

  • Pharmacology and Toxicology
  • Neuroscience
  • Immunology

Background:

  • Biphasic dose-response relationships are frequently observed with opiate administration.
  • These responses impact a wide array of physiological and cellular functions.

Purpose of the Study:

  • To analyze the quantitative features of opiate-induced biphasic dose-response relationships.
  • To investigate the variability in dose ranges for these responses.
  • To explore the underlying mechanistic aspects of observed biphasic effects.

Main Methods:

  • Review and analysis of existing data on opiate biphasic responses in animal models.
  • Quantitative assessment of dose-response curves, focusing on maximum response and dose range.
  • Mechanistic evaluation of identified biphasic dose-response relationships.

Related Experiment Videos

Main Results:

  • Opiates commonly elicit biphasic responses across diverse endpoints including blood pressure, neuronal function, and immune cell migration.
  • Maximum stimulatory responses were generally modest (10-70% above controls).
  • Significant variation was observed in the effective dose ranges, spanning several orders of magnitude (10^1 to 10^10).

Conclusions:

  • Biphasic opiate responses are a common phenomenon with conserved maximum effect magnitudes but highly variable dose dependencies.
  • The marked variation in dose range necessitates detailed mechanistic studies to understand these complex pharmacological profiles.