Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amyloid beta-peptide: biphasic dose responses.

E J Calabrese1

  • 1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu

Critical Reviews in Toxicology
|August 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy.

Mechanisms of ageing and development·2022
Same author

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose.

Human & experimental toxicology·2019
Same author

Funding trends in hormetic research.

Human & experimental toxicology·2019
Same author

Originator of the hormesis concept: Rudolf Virchow or Hugo Schulz.

Human & experimental toxicology·2017
Same author

Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders.

Journal of neuroscience research·2016
Same author

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Brain research·2016
Same journal

Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology.

Critical reviews in toxicology·2026
Same journal

Addendum.

Critical reviews in toxicology·2026
Same journal

Inhalation exposure and health effects of copper particles in the context of occupational exposure limit derivation.

Critical reviews in toxicology·2026
Same journal

Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison.

Critical reviews in toxicology·2026
Same journal

Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors.

Critical reviews in toxicology·2026
Same journal

The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies.

Critical reviews in toxicology·2026
See all related articles

Amyloid beta-peptide shows both beneficial and harmful effects on nerve cells, depending on its concentration. Reactive oxygen species play a key role in these dual effects, highlighting the importance of dosage in Alzheimer's disease research and treatment.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Amyloid beta-peptide (Aβ) is implicated in Alzheimer's disease.
  • The dual role of Aβ, neurotrophic and neurotoxic, is under investigation.

Purpose of the Study:

  • To investigate the concentration-dependent effects of amyloid beta-peptide on neuronal function.
  • To elucidate the role of reactive oxygen species in mediating Aβ's effects.

Main Methods:

  • Experimental studies on amyloid beta-peptide concentration.
  • Analysis of reactive oxygen species production and neuronal responses.

Main Results:

  • Low concentrations of Aβ exhibit neurotrophic effects.
  • High concentrations of Aβ demonstrate neurotoxic effects.

Related Experiment Videos

  • Reactive oxygen species mediate both neurotrophic and neurotoxic responses.

    • Conclusions:

    • Amyloid beta-peptide may have a biological function within a specific optimal concentration range.
    • Understanding the dose-dependent effects of Aβ is crucial for Alzheimer's disease therapeutics.
    • Targeting reactive oxygen species could be a therapeutic strategy for Alzheimer's disease.