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Cell migration/chemotaxis: biphasic dose responses
1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
Critical Reviews in Toxicology
|August 16, 2001
Abstract:
The dose-dependent effects of chemoattractants on target cell migration such as tumor cells, fibroblasts, and especially neutrophils were assessed. In general, the dose-response characteristics were strikingly biphasic in nature and were independent of both the target tissue and chemoattractant agent. The assessment included evaluations of the quantitative features of the dose-response relationship, mechanistic foundations of the biphasic responsiveness and clinical applications.