Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent Ehrlichia chaffeensis infection in white-tailed deer.

W R Davidson1, J M Lockhart, D E Stallknecht

  • 1Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens 30602, USA.

Journal of Wildlife Diseases
|August 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No evidence for homosubtypic immunity of influenza H3 in Mallards following vaccination in a natural experimental system.

Molecular ecology·2016
Same author

Expression Kinetics of RANTES and MCP-1 in the Brain of Deer Mice (Peromyscus maniculatus) Infected with Vesicular Stomatitis New Jersey Virus.

Journal of comparative pathology·2016
Same author

A 5-Year Retrospective Review of Avian Diseases Diagnosed at the Department of Pathology, University of Georgia.

Journal of comparative pathology·2016
Same author

Pathogenesis of Vesicular Stomatitis New Jersey Virus Infection in Deer Mice ( Peromyscus maniculatus) Transmitted by Black Flies ( Simulium vittatum).

Veterinary pathology·2016
Same author

Molecular evolution of epizootic hemorrhagic disease viruses in North America based on historical isolates using motif fingerprints.

Virus genes·2016
Same author

Environmental Stability of Swine and Human Pandemic Influenza Viruses in Water under Variable Conditions of Temperature, Salinity, and pH.

Applied and environmental microbiology·2016

White-tailed deer experimentally infected with Ehrlichia chaffeensis develop persistent infections. These deer exhibit prolonged rickettsemia and potential recrudescence, highlighting their role in Ehrlichia chaffeensis epidemiology.

Area of Science:

  • Veterinary Infectious Diseases
  • Zoonotic Disease Epidemiology
  • Microbiology and Immunology

Background:

  • Ehrlichia chaffeensis is an important tick-borne pathogen affecting both animals and humans.
  • White-tailed deer (Odocoileus virginianus) are known reservoirs for various pathogens, but their role in E. chaffeensis persistence requires further elucidation.

Purpose of the Study:

  • To investigate the duration and persistence of Ehrlichia chaffeensis infection in white-tailed deer following experimental inoculation.
  • To characterize the clinical, serological, and microbiological course of E. chaffeensis infection in deer.

Main Methods:

  • Intravenous inoculation of four white-tailed deer with a deer-origin E. chaffeensis isolate.
  • Monitoring infection via indirect fluorescent antibody (IFA) assays, polymerase chain reaction (PCR), and bacterial culture over a 9-month period.

Related Experiment Videos

  • Assessment for clinical signs, hematologic abnormalities, and gross/microscopic lesions.

    • Main Results:

    • All inoculated deer became rickettsemic within 24 days post-inoculation and developed high antibody titers.
    • Persistent rickettsemia was confirmed for up to 108 days, with recrudescence observed in one deer.
    • Infection was detected via PCR in bone marrow and lymph nodes late in the study (278 DPI); no clinical signs or lesions were observed.

    Conclusions:

    • White-tailed deer can become persistently infected with Ehrlichia chaffeensis, experiencing prolonged rickettsemia and potential recrudescence.
    • Deer serve as a significant reservoir, underscoring their critical role in the epidemiology and transmission of E. chaffeensis.