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Antifungal drug susceptibility testing and resistance in Aspergillus

David W. Warnock1, Beth A. Arthington-Skaggs, Ren-Kai Li

  • 1Mycotic Diseases Branch, Centers for Disease Control Prevention, Atlanta, USA

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|August 16, 2001
PubMed

Insights

Standardized antifungal drug susceptibility testing for Aspergillus species is crucial due to emerging resistance in immunocompromised patients. This review covers in vitro methods and their correlation with clinical outcomes for invasive aspergillosis treatment.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Aspergillus species are primary pathogens causing invasive mold infections in immunocompromised individuals.
  • Emerging antifungal resistance necessitates standardized susceptibility testing for filamentous fungi.

Purpose of the Study:

  • To review current and developing in vitro antifungal drug susceptibility testing methods for Aspergillus species.
  • To evaluate the correlation between in vitro test results and in vivo clinical outcomes.
  • To discuss mechanisms and clinical significance of resistance to antifungal agents used in aspergillosis treatment.

Main Methods:

  • Review of established and novel in vitro susceptibility testing methodologies for Aspergillus.
  • Analysis of studies correlating in vitro antifungal activity with clinical efficacy in patients.
  • Examination of documented mechanisms of antifungal resistance in Aspergillus.

Main Results:

  • Development of standardized in vitro testing methods is ongoing.
  • Correlation between in vitro susceptibility and in vivo response is being established.
  • Understanding resistance mechanisms is vital for effective treatment strategies.

Conclusions:

  • Standardized antifungal susceptibility testing for Aspergillus is essential for managing invasive infections.
  • In vitro data, when correlated with clinical outcomes, aids in optimizing treatment for aspergillosis.
  • Monitoring and understanding antifungal resistance are critical for improving patient care.

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