Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ongoing evolution of strand composition in bacterial genomes.

E P Rocha1, A Danchin

  • 1Atelier de BioInformatique, Université Paris VI, Paris, France. erocha@abi.snv.jussieu.fr

Molecular Biology and Evolution
|August 16, 2001
PubMed
Summary

Replication strand bias in bacterial genomes is driven by asymmetric substitutions, not just cytosine deamination. Genes adapting to new strands rapidly incorporate these biased substitutions, influencing genome evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ti-15Mo Alloy Decreases the Stress Concentration in Mandibular Angle Fracture Internal Fixation Hardware.

Journal of maxillofacial and oral surgery·2020
Same author

Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption.

Journal of periodontal research·2018
Same author

The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col.

Molecular microbiology·2017
Same author

Escherichia coli molecular genetic map (1000Kbp):update.

Molecular microbiology·2017
Same author

Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325° to 333deg.

Molecular microbiology·2017
Same author

Influence of customized composite resin fibreglass posts on the mechanics of restored treated teeth.

International endodontic journal·2011

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Replication strand bias is a key evolutionary factor in bacterial genome evolution.
  • Compositional asymmetry in genomes suggests underlying substitution biases.

Purpose of the Study:

  • Identify specific substitutions driving replication strand bias.
  • Investigate the role of asymmetric deamination and gene strand switching.

Main Methods:

  • Analysis of compositional asymmetry in 28 bacterial genomes.
  • Examination of substitutions in Chlamydia and Bacillus species' genes.
  • Development of a model based on substitution asymmetries.

Main Results:

  • Asymmetric deamination partially explains bias but not all variance.

Related Experiment Videos

  • Strand bias is an ongoing process in Chlamydia species.
  • Genes switching strands rapidly adapt via asymmetric substitutions (C-->T, A-->G, C-->G).

    • Conclusions:

    • A comprehensive model incorporating substitution asymmetries explains strong strand bias in bacterial genomes.
    • Asymmetric substitutions are crucial for genome evolution and adaptation.