An Eulerian path approach to DNA fragment assembly

P A Pevzner1, H Tang, M S Waterman

  • 1Department of Computer Science and Engineering, University of California, San Diego, La Jolla, USA.

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...