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Related Experiment Videos

Aspirin dosages for the dog.

R A Yeary, R J Brant

    Journal of the American Veterinary Medical Association
    |July 1, 1975
    PubMed
    Summary

    Determining optimal aspirin dosage for dogs is crucial. A maintenance dose of 25 to 35 mg/kg every 8 hours is recommended to achieve therapeutic serum salicylate concentrations while avoiding adverse effects like emesis.

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    Area of Science:

    • Veterinary Pharmacology
    • Animal Toxicology

    Background:

    • Aspirin is commonly used in veterinary medicine.
    • Establishing safe and effective dosages in dogs is essential for therapeutic success.
    • Pharmacokinetic data from humans can inform canine dosing, but requires validation.

    Purpose of the Study:

    • To determine optimal aspirin dosages for Basset Hounds based on human pharmacokinetic data.
    • To evaluate the efficacy and safety of different aspirin dosing regimens in dogs.
    • To establish target serum salicylate concentrations for effective canine pain management.

    Main Methods:

    • Aspirin dosages were calculated using published human pharmacokinetic data.
    • The study involved 3 male and 3 female Basset Hounds.
    • Serum salicylate concentrations and emesis were monitored at various dosages and intervals.

    Main Results:

    • A dosage of 50 mg/kg every 12 hours led to frequent emesis.
    • A dosage of 25 mg/kg every 12 hours prevented emesis but failed to maintain therapeutic serum salicylate levels (10-30 mg/100 ml).
    • A dosage of 25 mg/kg every 8 hours achieved serum salicylate concentrations of 12.5-17.8 mg/100 ml.

    Conclusions:

    • A maintenance dosage of 25 to 35 mg/kg of aspirin every 8 hours is optimal for dogs.
    • This dosage regimen is extrapolated from human data and aims to balance efficacy and safety.
    • Further studies may be needed to confirm these findings across different canine breeds and conditions.

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