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Non-nucleoside reverse transcriptase inhibitor failure impairs HIV-RNA responses to efavirenz-containing salvage
S L Walmsley1, D V Kelly, A L Tseng
1Toronto General Hospital Immunodeficiency Clinic, University Health Network, University of Toronto, Ontario, Canada.
AIDS (London, England)
|August 16, 2001
Abstract:
In a retrospective cohort study of salvage antiretroviral combination therapy including efavirenz, 60% of 51 patients were able to suppress HIV RNA by at least 1 log10 or to less than 50 copies/ml. A lack of the previous use of non-nucleoside reverse transcriptase inhibitors was the only factor predictive of response on multivariate analysis. No patient with a viral isolate with an increased IC50 to efavirenz by virtual phenotype had a virological response