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[Doksazozin "Cardura" in acute urinary retention caused by benign prostatic hyperplasia]

T S Perepanova, A A Kamalov, V N Siniukhin

    Urologiia (Moscow, Russia : 1999)
    |August 17, 2001
    PubMed

    Insights

    Doxazosin, an alpha 1-adrenoblocker, effectively treats acute ischuria (AI) caused by benign prostatic hyperplasia (BPH), restoring spontaneous urination in over half of patients. This drug offers a valuable therapeutic option for BPH-related urinary retention.

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Acute ischuria (AI) in benign prostatic hyperplasia (BPH) is primarily managed with bladder catheterization.
    • AI stems from anatomical obstruction, detrusor energy imbalance, and smooth muscle hypertonia.
    • Alpha 1-adrenoreceptor activity contributes to the dynamic obstruction component in BPH.

    Purpose of the Study:

    • To evaluate the efficacy of the alpha 1-adrenoblocker doxazosin in treating AI caused by BPH.
    • To compare doxazosin's effectiveness against placebo in restoring spontaneous urination.

    Main Methods:

    • A prospective, randomized, placebo-controlled study involving 36 BPH patients with AI.
    • Patients received either doxazosin or placebo after initial bladder catheterization and a 12-hour randomization period.

    Main Results:

    • Spontaneous urination was restored in 55.5% of all patients.
    • Doxazosin led to restoration in 63.3% of patients, compared to 16.6% in the placebo group.
    • 37.9% of doxazosin-treated patients were discharged for outpatient alpha-blocker therapy, avoiding immediate surgery.

    Conclusions:

    • Doxazosin significantly increases the likelihood of spontaneous urination recovery in AI patients with BPH.
    • Doxazosin provides a therapeutic window for surgical preparation and potential outpatient management.
    • Further investigation into long-term alpha-blocker therapy post-AI resolution in BPH is warranted.

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