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Controlled release from an electrorheological fluid dosage form: experimental results for a prototype system.
A K Kamal1, S K Nutalapati, T Jochsberger
1Dept. of Pharmaceutics and Industrial Pharmacy, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, 75 DeKalb Ave., Brooklyn, NY 11201, USA.
PDA Journal of Pharmaceutical Science and Technology
|August 17, 2001
Summary
This study introduces a novel controlled-release technology using electrorheological fluids (ERF). Applying an electric field significantly increased drug release, suggesting ordered starch particles reduce system tortuosity.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Chemical Engineering
Background:
- Controlled-release drug delivery systems are crucial for therapeutic efficacy.
- Electrorheological fluids (ERF) offer tunable properties under electric fields.
- Investigating ERF for drug release modulation presents a novel approach.
Purpose of the Study:
- To develop and investigate a new controlled-release technology based on electrorheological fluids.
- To evaluate the effect of electric fields on drug release using a model system.
- To understand the underlying mechanism of electric field-induced drug release.
Main Methods:
- A model system was created using humidified starch (20% w/w) in olive oil as the ERF.
- Benzocaine (BZN) was used as the model drug, released into 1N HCl.
- Drug release was measured using UV spectroscopy at various temperatures (25-45°C) and electric fields (0 V and 290 V).
Main Results:
- Application of an electric field significantly increased BZN release by approximately 53% at 25°C.
- Control studies without starch filler showed minimal electric field effect on release.
- The increase in release rate due to the electric field diminished with increasing temperature.
Conclusions:
- The results support the hypothesis that electric fields induce ordering of starch particles, reducing system tortuosity and enhancing drug release.
- This ERF-based system demonstrates potential for tunable controlled-release applications.
- Further studies are needed to definitively prove the ordering mechanism.