Related Experiment Videos
Synthesis and anthelmintic activity of 3,6-disubstituted-7H-s-triazolo(3,4-b)(1,3,4)thiadiazines
B A Nadkarni1, V R Kamat, B G Khadse
1Department of Chemotherapy, Haffkine Institute, Mumbai, India. bharatinadkarni@usa.net
Arzneimittel-Forschung
|August 17, 2001
Abstract:
A series of 3,6-disubstituted-7H-s-triazolo(3,4-b)(1,3,4)thiadiazines was synthesized by the condensation of the appropriate 3-substituted-4-amino-5-mercapto (1,2,4) triazoles with substituted phenacyl bromides in alcoholic medium. These compounds have been studied for their in vivo anthelmintic activity in albino mice. A number of compounds showed promising activity when given by the oral route.