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Photoinduced DNA cleavage by cyclopentadienyl metal complexes conjugated to DNA recognition elements
A L Hurley1, M P Maddox, T L Scott
1Department of Chemistry, Emory University, 1515 Pierce Dr., Atlanta, Georgia 30322, USA.
Organic Letters
|August 17, 2001
Abstract:
[structure: see text]. DNA recognition elements have been attached to CpW(CO)3CH3 and CpW(CO)3Ph, which produce methyl and phenyl radicals that cleave DNA upon photolysis. The inclusion of binding moieties in 3 increases the efficiency but not the selectivity of strand scission over that seen in the simple unfunctionalized complex, while 11 cleaves preferentially at T sites within AT-rich tracts.