To be or not to be: a question of B-Raf?

W Kolch1

  • 1Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, UK. wkolch@beatson.gla.ac.uk

Trends in Neurosciences
|August 17, 2001
PubMed

Related Concept Videos

Buoyancy01:12

Buoyancy

When an object is placed in a fluid, it either floats or sinks. All objects in a fluid experience a buoyant force. For example, a metal ball sinks, while a rubber ball floats. Similarly, a submarine can sink and float by adjusting its buoyancy.  The concept of buoyancy raises several interesting questions. For instance, where does this buoyant force come from? How much buoyant force is required to make an object sink or float? Do objects that sink get any support at all from the fluid? 
To get...
Buoyancy and Stability for Submerged and Floating Bodies01:11

Buoyancy and Stability for Submerged and Floating Bodies

In fluid mechanics, buoyancy and stability are key concepts for understanding the behavior of submerged and floating bodies. When a stationary body is fully or partially submerged in a fluid, the fluid exerts a force on the body known as the buoyant force. This force acts vertically upward through a point called the center of buoyancy, which is the center of the displaced fluid volume. According to Archimedes' principle, the magnitude of the buoyant force is equal to the weight of the fluid...
Density and Archimedes' Principle01:05

Density and Archimedes' Principle

When a lump of clay is dropped into water, it sinks. But if the same lump of clay is molded into the shape of a boat, it starts to float. Because of its shape, the clay boat displaces more water than the lump and experiences a greater buoyant force, even though its mass is the same. The same holds true for steel ships. The average density of an object majorly determines if the object will float. If an object's average density is less than that of the surrounding fluid, it will float. The reason...
Prismatic Beams: Problem Solving01:15

Prismatic Beams: Problem Solving

In the design of a supported timber beam subjected to a distributed load, both the beam's physical dimensions and the timber's characteristics, such as its grade and species, are critical. These factors determine the allowable stress values, which are crucial for calculating the necessary beam depth to ensure structural integrity and safety.
The design begins with analyzing the beam as a free body to identify moments and force balances, thereby determining support reactions. Next, the designer...
Beams01:30

Beams

Beams are integral components of structural engineering and construction, designed to support loads applied at various points along their length. These long, straight members can be classified based on geometry, cross-section, support type, and equilibrium condition.
Based on geometry, beams can be straight, tapered, or curved. Straight beams are the most common type and have a constant cross-section throughout their length. Tapered beams, on the other hand, have a varying cross-section along...
Design of Prismatic Beams for Bending01:23

Design of Prismatic Beams for Bending

The design of prismatic beams, structural elements with a uniform cross-section, focuses on ensuring safety and structural integrity under load. The design process begins by determining the allowable stress, either from material properties tables, or by dividing the material's ultimate strength by a safety factor. This safety factor is essential for accommodating uncertainties, and varies depending on the material—timber, steel, or concrete—with each having unique strength and stress...