Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial function and coronary artery disease.

S Kinlay1, P Libby, P Ganz

  • 1Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. skinllay@rics.bwh.harvard.edu

Current Opinion in Lipidology
|August 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: A panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2).

Environmental research·2021
Same author

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. Effects of Personal and Ambient Concentrations of Ozone and Other Pollutants on Cardiovascular and Pulmonary Function.

Research report (Health Effects Institute)·2020
Same author

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes.

Research report (Health Effects Institute)·2020
Same author

Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial.

Alimentary pharmacology & therapeutics·2018
Same author

Inflammation and plaque vulnerability.

Journal of internal medicine·2015
Same author

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development.

Journal of thrombosis and haemostasis : JTH·2014
Same journal

Editorial introduction.

Current opinion in lipidology·2026
Same journal

Heterozygosity for pathogenic variants in familial chylomicronemia syndrome genes: from carrier state to complex trait.

Current opinion in lipidology·2026
Same journal

Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.

Current opinion in lipidology·2026
Same journal

The role of metabolic profiling and dietary intervention in the early diagnosis and prevention of atherosclerosis.

Current opinion in lipidology·2026
Same journal

A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients?

Current opinion in lipidology·2026
Same journal

Inflammation and atherosclerotic cardiovascular disease: where do we go from here?

Current opinion in lipidology·2026
See all related articles

Endothelial vasomotor function, crucial for cardiovascular health, is impaired by lipids and stress, affecting nitric oxide bioavailability and inflammation. Understanding these mechanisms offers new therapeutic targets for vascular disease.

Area of Science:

  • Cardiovascular Science
  • Endothelial Biology
  • Molecular Medicine

Background:

  • The endothelium regulates vascular tone, inflammation, and thrombosis through various signaling substances.
  • Endothelial vasomotor function serves as a key indicator of overall endothelial health and cardiovascular disease risk.
  • Impaired endothelial function is linked to cardiovascular disease, with lipids and oxidant stress playing significant roles.

Purpose of the Study:

  • To explore the multifaceted roles of endothelial function in cardiovascular health.
  • To investigate the impact of lipids, oxidant stress, and biomechanical forces on endothelial function.
  • To identify potential therapeutic targets for endothelial dysfunction.

Main Methods:

  • Assessing endothelial vasomotor function as a proxy for other endothelial activities.

Related Experiment Videos

  • Examining the roles of low-density lipoprotein cholesterol and oxidant stress in reducing nitric oxide bioavailability.
  • Investigating the effects of biomechanical forces, such as shear stress, on endothelial gene expression and activation.
  • Analyzing the structural and functional impact of lipids and oxidant stress on endothelial caveolae and nitric oxide synthase activity.

    • Main Results:

    • Lipids and oxidant stress impair endothelial function by reducing nitric oxide bioavailability and activating pro-inflammatory pathways like nuclear factor kappa B.
    • Disturbed blood flow (low shear stress) promotes endothelial dysfunction and inflammation, while normal shear stress is protective.
    • Lipid and oxidant stress-induced damage to caveolae adversely affects endothelial nitric oxide synthase activity.
    • Lipid-independent pathways of endothelial activation and genetic polymorphisms in nitric oxide synthase contribute to endothelial dysfunction and vascular disease variability.

    Conclusions:

    • Endothelial vasomotor function is a critical determinant of cardiovascular health, influenced by lipids, oxidant stress, and biomechanical forces.
    • Dysfunctional endothelial pathways, including those involving nitric oxide and caveolae, are implicated in atherosclerosis and vascular disease.
    • Emerging lipid-independent pathways and genetic factors offer novel insights and potential therapeutic strategies for managing endothelial dysfunction.