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Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Thrombolytic therapy and myocardial infarction

C L Berry

    Journal of Clinical Pathology
    |May 1, 1975
    PubMed

    Insights

    Streptokinase treatment after myocardial infarction can cause significant bleeding in damaged heart tissue. This hemorrhage is likely due to restored blood flow to the infarcted areas.

    Area of Science:

    • Cardiovascular pathology
    • Thrombolytic therapy

    Background:

    • Myocardial infarction (MI) is a leading cause of death.
    • Thrombolytic agents like streptokinase are used to restore blood flow after MI.

    Purpose of the Study:

    • To investigate the histopathological effects of streptokinase treatment in patients with myocardial infarction.

    Main Methods:

    • Histopathological examination of 27 hearts from patients treated with streptokinase post-MI.
    • Comparison with control hearts.

    Main Results:

    • Identified massive interstitial hemorrhage in necrotic cardiac tissue in some treated patients.
    • This was the primary histopathological difference observed compared to controls.

    Conclusions:

    • Massive interstitial hemorrhage is a potential complication of streptokinase therapy post-MI.
    • Hemorrhage is likely linked to the re-establishment of circulation in infarcted regions.

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