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[Effects of intestinal endotoxemia on the development of cirrhosis in rats]
1Department of Infectious Diseases, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Objective:
To explore the effect of endotoxin on the development of cirrhosis.
Methods:
The cirrhosis model with intestinal endotoxemia was made by oral intake of 0.03% thioacetamide for four months to observe the effect of endotoxin on the hepatic collagen contents in both thioacetamide and thioacetamide + lipopolysaccharide groups and to detect the contents of tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and the hepatic homogenate.
Results:
The contents of TNF-alpha, ET-1, NO, and MDA in the plasma and the hepatic homogenate and the content of collagen in the hepatic tissue in the two groups were higher than those in the normal control group.
Conclusions:
Endotoxin can accelerate liver fibrosis and the formation of cirrhosis.
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