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[Clinical study on hepatitis D virus-positive patients died from severe hepatitis B]
1Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Objective:
To investigate the role of hepatitis D virus (HDV) in the development of severe hepatitis B.
Methods:
Seventy-six HDV-positive patients died from severe hepatitis B were compared with 244 HDV-negative patients from severe hepatitis B in clinical manifestations, signs, complications and main biochemical indexes at the same period.
Results:
HDV-positive patients had obvious ascites, abdominal distension, digestive tract hemorrhage as compared with the HDV-negative ones (P<0.05). There were significant differences in hepatorenal syndrome, bacterial infection, manifold complications, the levels of total bilirubin and alanine aminotransferase, and the activity of prothrombin between the patients of the two groups (P<0.01).
Conclusions:
HDV can aggravate severe hepatitis B.