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Updated: Apr 12, 2026

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time
Published on: October 12, 2018
Long-term exposures to higher environmental temperature and body temperature: effect of chlorpromazine in relation to
1Department of Biochemistry, College of Science, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India.
Abstract:
Treatment with a single dose of chlorpromazine (CPZ; 1 mg/kg, ip) at room temperature (28 degrees +/-0.5 degrees C) significantly reduced body temperature by its anticholinergic action. Long-term exposures to higher environmental temperature (40 degrees +/-0.5 degrees C, 2 h/day, for 30 consecutive days) increased body temperature significantly by reduction of hypothalamic GABAergic activity, but this increase in body temperature was attenuated from that observed with a single exposure to higher environmental temperature (40 degrees C for 2 h). Treatment with a single dose of CPZ on the last day of 30 consecutive days of exposures to higher environmental temperature increased body temperature of rats more than that observed with long-term exposures to higher environmental temperature possibly due to (i) reduction of hypothalamic GABAergic activity, (ii) heat dissipation and (iii) reverse-anticholinergic action of CPZ at higher environmental temperature.
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