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Updated: Oct 5, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

Coronary artery bypass grafting for patients with non-dialysis-dependent renal dysfunction (serum creatinine > or

H Hirose1, A Amano, A Takahashi

  • 1Department of Cardiovascular Surgery, Kobari General Hospital, 29-1 Yokouchi, Noda City, 278-8501, Chiba, Japan. genex@nifty.com

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|August 18, 2001
PubMed

Insights

Patients with renal dysfunction undergoing coronary artery bypass grafting (CABG) face higher operative risks and poorer long-term outcomes. Off-pump CABG may offer a faster recovery for these high-risk cardiac surgery patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Cardiac Surgery

Background:

  • Renal dysfunction is a known risk factor for coronary atherosclerosis.
  • Patients with chronic kidney disease often present with cardiovascular complications.

Purpose of the Study:

  • To evaluate the outcomes of coronary artery bypass grafting (CABG) in patients with impaired renal function.
  • To compare the results of off-pump versus on-pump CABG in patients with serum creatinine ≥ 2.0 mg/dl.

Main Methods:

  • Retrospective analysis of isolated CABG patients from May 1991 to April 2000.
  • Comparison of non-dialysis-dependent patients with serum creatinine ≥ 2.0 mg/dl (Group R, n=59) against controls (serum creatinine < 2.0 mg/dl, Group C, n=1666).

Main Results:

  • Group R had longer operative times and more frequent major complications (28.8% vs 10.7%) and mortality (6.8% vs 0.5%).
  • Off-pump CABG showed faster recovery than on-pump CABG in Group R.
  • 3-year survival (75.3% vs 96.9%) and cardiac event-free rates (76.7% vs 87.3%) were significantly lower in Group R.

Conclusions:

  • Decreased renal function significantly increases operative risks and prolongs hospital care after CABG.
  • Long-term survival and cardiac event-free rates are inferior in patients with renal dysfunction compared to those with normal renal function, even after successful revascularization.
Abstract

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