Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluctuations and the Hofmeister effect.

A Neagu1, M Neagu, A Dér

  • 1University of Medicine and Pharmacy Timisoara, Department of Biophysics and Medical Informatics, RO-1900, Timisoara, Romania. ANeagu@medinfo.umft.ro

Biophysical Journal
|August 18, 2001
PubMed
Summary

This study proposes a kinetic theory for the Hofmeister effect, explaining protein solubility changes due to salt cosolutes. The model successfully predicts experimental data and offers new ways to quantify salt-induced thermodynamic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024

Area of Science:

  • Physical Chemistry
  • Biophysics
  • Chemical Thermodynamics

Background:

  • The Hofmeister effect describes alterations in protein solubility induced by neutral electrolyte cosolutes.
  • Understanding the molecular mechanisms behind these solubility changes is crucial for various biological and chemical processes.

Purpose of the Study:

  • To develop a kinetic theory for the Hofmeister effect based on stochastic fluctuations of free energy barriers.
  • To provide a framework for quantifying the influence of salts on protein solubility and thermodynamic properties.

Main Methods:

  • A kinetic theory was developed by adding exponentially correlated noise, proportional to salt concentration, to energy levels.
  • The time-dependence of mean protein concentration was calculated under these conditions.

Related Experiment Videos

  • The proposed theory was validated against experimental data for both salting-in and salting-out agents.

    • Main Results:

    • The theory reproduces the Setschenow equation under specific conditions (low noise correlation time).
    • Experimental data for salting-in agents were well-fitted, while salting-out agents required a modified model with two dichotomic fluctuations.
    • The findings suggest differing contributions of electrostatic and donor/acceptor interactions at varying salt concentrations.

    Conclusions:

    • The proposed kinetic theory offers a novel approach to metricate Hofmeister effects.
    • The formalism provides thermodynamic quantities that account for salt influence.
    • This theoretical framework can be extended to describe other kinetic phenomena involving cosolutes.