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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
J S Thompson1, S A Bixler, F Qian
1Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
Science (New York, N.Y.)
|August 18, 2001
Summary
Scientists discovered a new receptor, BAFF-R, crucial for B cell survival. This finding explains how B cell activation factor (BAFF) regulates B cell homeostasis and identifies BAFF-R as the primary receptor for mature B cell survival.
Area of Science:
- Immunology
- Molecular Biology
Background:
- B cell homeostasis is regulated by the B cell activation factor (BAFF) from the tumor necrosis factor (TNF) family.
- BAFF is known to interact with BCMA and TACI receptors.
Purpose of the Study:
- To identify and characterize novel receptors for BAFF.
- To elucidate the role of these receptors in B cell function.
Main Methods:
- Ligand-receptor binding assays.
- Genetic analysis of A/WySnJ mice with a disrupted BAFF-R locus.
- Phenotypic analysis of B cell populations.
Main Results:
- A third BAFF receptor, termed BAFF-R, was identified.
- BAFF-R exhibits specific binding to BAFF, suggesting a unique interaction.
- Disruption of the BAFF-R locus in A/WySnJ mice leads to a B cell phenotype similar to BAFF-deficient mice.
Conclusions:
- BAFF-R is a principal receptor for BAFF.
- BAFF-R plays a critical role in mediating mature B cell survival and maintaining B cell homeostasis.
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