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Hysteroscopic findings in 344 women with recurrent spontaneous abortion
1Department of Obstetrics and Gynaecology, University of Rome Tor Vergata, Ospedale San Giovanni Calibita Fatebenefratelli-Isola Tiberina, 00186 Rome, Italy.
Study Objective:
To evaluate the prevalence of different anatomic factors in women with recurrent spontaneous abortion (RSA).
Design:
Retrospective analysis over 9 years (Canadian Task Force classification II-2).
Setting:
University hospital-affiliated endoscopic unit.
Patients:
Three hundred forty-four consecutive patients with RSA and 922 controls referred for abnormal uterine bleeding.
Intervention:
Diagnostic hysteroscopy.
Measurements And Main Results:
Major and minor uterine mullerian abnormalities (septate, unicornuate uteri) were found significantly more often in women with RSA than in controls (32% vs 6%, p <0.001). The frequency of acquired uterine anomalies (submucous myomas, polyps) was significantly higher in controls (32% vs 9%, p <0.001). No significant differences were observed between groups in frequency of adhesions (4% vs 2%).
Conclusion:
Major mullerian uterine abnormalities are associated with RSA, and minor uterine anomalies may be correlated with an increased risk of recurrent miscarriage.