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Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids
P Cos1, M Calomme, J B Sindambiwe
1Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
Planta Medica
|August 18, 2001
Abstract:
Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i. e., the maximal non-toxic dose divided by the IC(50) value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.