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Evidence for superantigen involvement in severe group a streptococcal tissue infections

A Norrby-Teglund1, P Thulin, B S Gan

  • 1Center for Infectious Medicine, Karolinska Institutet, Department of Medicine, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. Anna.Norrby-Teglund@medhs.ki.se

The Journal of Infectious Diseases
|August 18, 2001
PubMed
Summary

Severe invasive group A streptococcus (GAS) infections show higher bacterial loads and specific immune responses in inflamed tissues. Superantigens and Th1 cytokines play a critical role in these dangerous GAS tissue infections.

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