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[Causes of lethal outcomes in croup syndrome in children]

M S Savenkova, L M Korobko, G G Kotsyganova

    Vestnik Otorinolaringologii
    |August 21, 2001
    PubMed

    Insights

    Children with croup syndrome often died from severe pneumonia and sepsis, particularly infants. Bacterial-viral infections resistant to antibiotics contributed to these fatal outcomes in children with underlying health issues.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Critical Care Medicine

    Context:

    • Retrospective analysis of 40 pediatric cases of croup syndrome with lethal outcomes.
    • Data collected from Morozov Children's Moscow City Hospital between 1985 and 1998.
    • Focus on demographic, clinical, and microbiological factors in fatal cases.

    Purpose:

    • To investigate the primary causes of mortality in children diagnosed with croup syndrome.
    • To identify risk factors and etiological agents associated with severe outcomes.
    • To evaluate the role of antibiotic resistance in treatment failures.

    Summary:

    • Severe pneumonia complications (92.5%) and sepsis (7.5%) were the main causes of death in children with croup.
    • Infants aged 0-2 years (70%) and boys (75%) were disproportionately affected.
    • Aggravated premorbid background was noted in all deceased children.
    • Microbiological findings revealed viral and bacterial (staphylococci, streptococci) co-infections resistant to common antibiotics.
    • Low systemic reactivity and resistant bacterial-viral associations were concluded as primary contributors to mortality.

    Impact:

    • Highlights the critical role of severe pneumonia and sepsis in pediatric croup mortality.
    • Underscores the vulnerability of young infants and male infants to fatal croup complications.
    • Emphasizes the challenge posed by antibiotic-resistant pathogens in treating severe pediatric infections.
    • Informs clinical practice regarding risk assessment and management strategies for severe croup syndrome.

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