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Related Experiment Videos

Changing trends in angioedema.

E G Cohen1, A M Soliman

  • 1Department of Otolaryngology and Bronchoesophagology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

The Annals of Otology, Rhinology, and Laryngology
|August 21, 2001
PubMed
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Angiotensin-converting enzyme inhibitor (ACEI) angioedema is increasingly reported. African-Americans may face higher risks, but prompt management with ACEI discontinuation and supportive care leads to recovery without fatalities.

Area of Science:

  • Medicine
  • Pharmacology
  • Emergency Medicine

Background:

  • Angioedema is a potentially life-threatening condition.
  • Angiotensin-converting enzyme inhibitors (ACEIs) are increasingly implicated in angioedema causation.

Purpose of the Study:

  • To retrospectively examine cases of angioedema.
  • To investigate the association between ACEI use and angioedema.
  • To identify risk factors and effective management strategies for ACEI-associated angioedema.

Main Methods:

  • Retrospective review of 64 angioedema cases between 1994 and 1998.
  • Analysis of patient demographics, ACEI usage, clinical presentation, and treatment outcomes.

Main Results:

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  • 58% of angioedema patients were using ACEIs.
  • 94% of all patients and 92% of ACEI-associated cases were African-American.
  • Tongue, lip, facial, and supraglottic edema were most common; 13% required intubation.
  • No deaths were reported with management including corticosteroids and antihistamines.

    • Conclusions:

    • ACEI-associated angioedema is more common than previously thought.
    • African-American patients may be at increased risk for ACEI-induced angioedema.
    • Observation, airway management, corticosteroids, and ACEI discontinuation are effective treatments.