Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Partial liquid ventilation improves lung function in ventilation-induced lung injury.

G F Vazquez de Anda1, R A Lachmann, S J Verbrugge

  • 1Dept of Anesthesiology, Erasmus University Rotterdam, The Netherlands.

The European Respiratory Journal
|August 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Authors reply: "AI in critical care: a roadmap to the future".

Journal of critical care·2026
Same author

How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025
Same author

Is Clinical Outcome Pathogen Related? Characteristics and Outcomes of ICU Patients with Severe Acute Respiratory Infections: Focusing on Respiratory Syncytial Virus, Human Metapneumovirus, Influenza Virus, and Parainfluenza Virus.

Journal of intensive care medicine·2025
Same author

AI in critical care: A roadmap to the future.

Journal of critical care·2025
Same author

Long-read sequencing identifies copy-specific markers of SMN gene conversion in spinal muscular atrophy.

Genome medicine·2025
Same author

Post COVID-19 Pandemic Increased Detection of Mycoplasma Pneumoniae in Adults Admitted to the Intensive Care.

Journal of clinical medicine·2024

Partial liquid ventilation using perfluorocarbon effectively restored lung function and gas exchange in rats with ventilation-induced lung injury. Maintaining perfluorocarbon levels is key for sustained benefits in lung mechanics.

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Mechanical ventilation with high peak inspiratory pressures (PIP) and low positive end-expiratory pressure (PEEP) can cause lung injury.
  • Ventilation-induced lung injury (VILI) leads to impaired lung function and mechanics.

Purpose of the Study:

  • To investigate if partial liquid ventilation (PLV) can restore lung function after VILI.
  • To evaluate the efficacy of different perfluorocarbon dosages in VILI models.

Main Methods:

  • Adult rats were subjected to VILI using high PIP without PEEP.
  • Animals received varying doses of perfluorocarbon (perflubron) or sham treatment.
  • Lung function, mechanics, and biochemical markers were assessed over a 2-hour observation period.

Related Experiment Videos

Main Results:

  • PLV significantly improved gas exchange and pulmonary function compared to standard care.
  • Benefits were observed despite high intra-alveolar protein concentrations.
  • Higher perflubron doses (10 and 20 mL/kg) showed notable improvements.

Conclusions:

  • Partial liquid ventilation with perfluorocarbon is a viable strategy to improve lung function in VILI.
  • Sustained therapeutic effects necessitate maintaining adequate perfluorocarbon levels due to potential loss.
  • PLV demonstrates potential for managing VILI, even in the presence of significant alveolar protein.