Aspects of epidermal ultrastructure

Some problems posed by primarily ultrastructural studies of the epidermis are highlighted and discussed, and on the whole it is concluded that purely morphologic observations are unlikely further to elucidate such questions as the nature and function of keratohyalin, or the dynamic aspects of the general keratinization process. The contribution of freeze-fracture studies to the understanding of the functional morphology of the epidermis is assessed, with particular reference to specialized contacts, and the stratum corneum. Passing reference is made to the epidermal nonkeratinocytes.