Related Experiment Video

Updated: Oct 5, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus

I Imoto1, A Pimkhaokham, Y Fukuda

  • 1Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan.

Biochemical and Biophysical Research Communications
|August 21, 2001
PubMed

Insights

Amplification of the SNO gene is frequently observed in esophageal squamous cell carcinomas (ESCs). This suggests SNO is a key driver in ESC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Esophageal squamous cell carcinoma (ESC) frequently exhibits amplification in the 3q26 chromosomal region.
  • Several genes within this region are implicated in cancer progression, including those involved in transforming growth factor-beta signaling.

Purpose of the Study:

  • To investigate the amplification and expression of four key genes (SNO, EVI1, TERC, PIK3CA) within the 3q26 amplicon in ESC.
  • To identify the most likely target gene responsible for ESC progression.

Main Methods:

  • Analysis of gene amplification and expression levels in ESC cell lines.
  • Examination of gene copy-number and expression correlation in primary ESC samples.

Main Results:

  • SNO gene amplification strongly correlated with increased expression, indicating amplification-dependent activation.
  • SNO amplification was detected in 11.4% of primary ESCs.
  • EVI1, TERC, and PIK3CA expression did not correlate with copy-numbers, despite similar amplification patterns for EVI1 and TERC.

Conclusions:

  • SNO is the most probable target gene within the 3q26 amplicon driving ESC progression.
  • The findings highlight SNO's critical role in the development of esophageal squamous cell carcinoma.

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...