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Updated: Aug 4, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Optimizing antibiotic therapy in the intensive care unit setting

M H Kollef1

  • 1Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes-Jewish Hospital, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA. kollefm@msnotes.wustl.edu

Critical Care (London, England)
|August 21, 2001
PubMed

Insights

Optimizing antibiotic use in intensive care units (ICUs) is crucial for improving patient outcomes and combating antimicrobial resistance. Strategies like antibiotic rotation and de-escalation therapy, monitored locally, are key to achieving this balance.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotics are frequently used in intensive care units (ICUs).
  • Antibiotic administration contributes to the development of antimicrobial resistance.
  • Unnecessary antibiotic use can negatively impact patient outcomes and drive resistance.

Purpose of the Study:

  • To review strategies for optimizing antimicrobial agent administration in ICUs.
  • To emphasize the importance of local monitoring programs for antibiotic utilization.
  • To highlight methods for evaluating the effectiveness of interventions against antimicrobial resistance.

Main Methods:

  • Review of current literature on antibiotic stewardship in critical care.
  • Discussion of strategies such as antibiotic rotation and de-escalation therapy.
  • Emphasis on the need for local ICU-based antibiotic surveillance programs.

Main Results:

  • Optimizing antibiotic use can improve patient outcomes.
  • Judicious antibiotic administration is essential to minimize the emergence of resistant pathogens.
  • Local monitoring is vital for assessing the impact of antimicrobial stewardship interventions.

Conclusions:

  • Implementing targeted strategies can enhance antimicrobial efficacy and reduce resistance.
  • Each ICU should establish programs to monitor antibiotic use and treatment effectiveness.
  • Local evaluation enables informed adjustments to antibiotic stewardship interventions.

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