Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat
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Updated: Oct 5, 2026
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
T J Kilpatrick1, S Phan, K Reardon
1The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.
Abstract:
A prominent side effect of Paclitaxel chemotherapy is sensorimotor peripheral neuropathy. Leukaemia inhibitory factor (LIF) supports the survival and regrowth of axotomised sensory and motor neurons and we therefore investigated if systemically administered LIF abrogated Paclitaxel-induced neuropathy. We found that whereas animals administered Paclitaxel alone exhibited a significant decrease in the percentage of large myelinated axons, this reduction was prevented by the co-administration of LIF.