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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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Abnormal contractile responses during dobutamine stress echocardiography in patients with idiopathic dilated

R M de Jong1, J H Cornel, H J Crijns

  • 1Department of Cardiology/Thorax Centre, University Hospital Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

European Journal of Heart Failure
|August 21, 2001
PubMed

Insights

In patients with idiopathic dilated cardiomyopathy, increased heart energy demand during dobutamine stress echocardiography often leads to reduced wall motion, suggesting an energy supply-demand mismatch contributes to this condition.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Chronic heart failure increases myocardial energy demand due to augmented wall stress.
  • Coronary vasoconstriction and endothelial dysfunction can reduce energy supply.
  • This creates a potential mismatch between myocardial energy demand and supply.

Purpose of the Study:

  • To investigate the effects of increased myocardial energy demand during dobutamine stress echocardiography.
  • To explore the relationship between energy demand and supply in idiopathic dilated cardiomyopathy.

Main Methods:

  • Sixteen patients with idiopathic dilated cardiomyopathy underwent dobutamine stress echocardiography.
  • Wall motion and thickening were assessed in 16 segments using a four-point scale.
  • Dobutamine was administered at 5-40 microg/min per kg bodyweight, with atropine if needed.

Main Results:

  • 69% of patients exhibited worsening wall motion or a biphasic response during dobutamine infusion.
  • Only three patients showed improvement in overall heart wall motion.
  • These findings indicate ischemia-like myocardial contractile responses under increased demand.

Conclusions:

  • A majority of patients with idiopathic dilated cardiomyopathy display reduced wall motion during increased demand.
  • These results support the hypothesis that an energy mismatch plays a key role in the pathophysiology of this condition.
Abstract

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