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Dapsone and sulfones in dermatology: overview and update
1Department of Dermatology, New York Presbyterian Medical Center, 161 Fort Washington Ave., New York, NY 10032, USA.
Journal of the American Academy of Dermatology
|August 21, 2001
Summary
Dapsone and sulfones are effective antibacterial and anti-inflammatory drugs for dermatologic disorders involving neutrophil and eosinophil accumulation. This review details their chemistry, use, and safety in dermatology.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Dapsone and sulfones have a 60-year history of use as antibacterial and anti-inflammatory agents.
- These drugs are particularly effective for dermatologic conditions marked by abnormal neutrophil and eosinophil accumulation.
Purpose of the Study:
- To provide an updated review of dapsone and sulfones in dermatology.
- To cover their chemistry, pharmacokinetics, clinical applications, mechanism of action, adverse effects, and drug interactions.
Main Methods:
- Literature review and synthesis of existing data on dapsone and sulfones in dermatologic practice.
Main Results:
- Dapsone demonstrates significant success in treating various dermatologic disorders.
- Key areas of efficacy include conditions with abnormal neutrophil and eosinophil activity.
Conclusions:
- Dapsone and sulfones remain valuable therapeutic agents in dermatology.
- A comprehensive understanding of their properties is crucial for optimal clinical use and safety.
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