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Genomics and drug discovery.

W A Haseltine1

  • 1Human Genome Sciences, Inc., 9410 Key West Ave., Rockville, MD 20850-3338, USA.

Journal of the American Academy of Dermatology
|August 21, 2001
PubMed
Summary

Genomics accelerates pharmaceutical drug discovery by identifying human genes for novel therapies. This approach has yielded four drugs in clinical trials, including treatments for wound healing and autoimmune diseases.

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Area of Science:

  • Genomics and Bioinformatics
  • Drug Discovery and Development
  • Molecular Biology

Background:

  • The pharmaceutical industry is exploring genomics for novel drug discovery.
  • Systematic gene isolation enables the development of protein, antibody, peptide, and gene-based drugs.

Purpose of the Study:

  • To highlight the application of a systematic genomics approach in pharmaceutical drug discovery.
  • To introduce novel drug candidates developed through genomics.

Main Methods:

  • Genomic research for the isolation of human genes.
  • Development of drugs targeting human proteins, antibodies, peptides, and genes.
  • Clinical trials for evaluating drug efficacy and safety.

Main Results:

  • Human Genome Sciences, Inc. pioneered a genomics-driven drug discovery model.
  • Four genomics-based drugs have entered clinical trials.
  • Repifermin (keratinocyte growth factor-2, KGF-2) is in development for wound healing and cancer therapy-induced mucositis.
  • B lymphocyte stimulator (BLyS) is being developed for immune system stimulation.
  • An anti-BLyS antibody drug is in advanced preclinical development for autoimmune diseases.

Conclusions:

  • Genomics provides a robust platform for pharmaceutical innovation.
  • The genomics approach has successfully generated multiple drug candidates for diverse therapeutic areas.
  • Further development of genomics-based therapeutics holds significant promise for unmet medical needs.

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