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Radiation-induced meningioma with a long latency period: a case report
E Boljesíková1, M Chorváth, P Hurta
1Radiotherapy Clinic, St Elisabeth Cancer Institute, Heydukova 10, 812 50 Bratislava, Slovakia. eboljesi@ousa.sk
Pediatric Radiology
|August 21, 2001
Abstract:
Multiple meningiomas were diagnosed in a 43-year-old man previously treated with high-dose craniospinal radiotherapy at the age of 7 years for medulloblastoma. We suggest that surveillance MRI after high-dose craniospinal radiotherapy should be extended to several (3-5) decades.
Insights
High-dose craniospinal radiotherapy for medulloblastoma can lead to multiple meningiomas decades later. Extended surveillance MRI is recommended for patients treated with this therapy.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Neurosurgery
Background:
- Medulloblastoma treatment in childhood often involves high-dose craniospinal radiotherapy.
- Long-term adverse effects of pediatric cancer treatments require ongoing investigation.
- The risk of secondary neoplasms after radiotherapy is a significant concern.
Observation:
- A 43-year-old male developed multiple meningiomas.
- The patient had a history of medulloblastoma treated with high-dose craniospinal radiotherapy at age 7.
- Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.
Findings:
- The development of multiple meningiomas suggests a potential long-term complication of high-dose craniospinal radiotherapy.
- The latency period between radiotherapy and meningioma diagnosis can span several decades.
Implications:
- Surveillance Magnetic Resonance Imaging (MRI) protocols following high-dose craniospinal radiotherapy should be extended.
- Consider extending surveillance for 3-5 decades post-treatment to detect late-onset secondary neoplasms like meningiomas.
- This case highlights the critical need for lifelong monitoring in medulloblastoma survivors.