Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methamphetamine self-administration by humans.

C L Hart1, A S Ward, M Haney

  • 1Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA. clh42@columbia.edu

Psychopharmacology
|August 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022
Same author

CHESS: The future direct geometry spectrometer at the second target station.

The Review of scientific instruments·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same author

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

Living reviews in relativity·2020
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
Same journal

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Psychopharmacology·2026
Same journal

OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.

Psychopharmacology·2026
See all related articles

Oral methamphetamine is a positive reinforcer in humans, as demonstrated by increased self-administration when active doses were available compared to placebo. Higher doses also led to greater positive subjective effects and reduced caloric intake.

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Addiction Research

Background:

  • Methamphetamine abuse presents a significant public health challenge.
  • The reinforcing properties of methamphetamine in humans require systematic investigation.

Purpose of the Study:

  • To quantify the reinforcing effects of oral methamphetamine in human participants.
  • To assess methamphetamine's reinforcing potential under controlled laboratory conditions.

Main Methods:

  • Eight healthy volunteers participated in a 20-day residential study.
  • Participants sampled oral methamphetamine doses (0, 5, 10 mg) and chose between methamphetamine or a $1 voucher over a 3-day period.
  • A choice procedure evaluated self-administration of methamphetamine versus the voucher.

Related Experiment Videos

Main Results:

  • Self-administration of methamphetamine significantly increased with active doses (5 mg and 10 mg) compared to placebo.
  • The 10 mg dose, but not the 5 mg dose, significantly enhanced positive subjective effects like "High" and "Stimulated."
  • Both active methamphetamine doses led to significant reductions in daily caloric intake.

Conclusions:

  • Oral methamphetamine acts as a positive reinforcer in humans.
  • These findings contribute to understanding methamphetamine's addictive potential.