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Increased tacrolimus levels during diarrhea.

B W Hochleitner1, C Bösmüller, H Nehoda

  • 1Department of Transplant Surgery, Innsbruck University Hospital, Anichstrasse 35, 6020 Innsbruck, Austria. Boris.Hochleitner@uibk.ac.at

Transplant International : Official Journal of the European Society for Organ Transplantation
|August 21, 2001
PubMed
Summary
This summary is machine-generated.

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Diarrhea can increase tacrolimus (FK506) levels in transplant patients, unlike cyclosporine. Monitoring is crucial during gastroenteritis to prevent tacrolimus toxicity and ensure levels remain therapeutic.

Area of Science:

  • Transplant medicine
  • Pharmacology

Background:

  • Diarrhea is known to decrease cyclosporine A levels.
  • Limited data exists on tacrolimus (FK506) levels during gastroenteritis.

Purpose of the Study:

  • To investigate tacrolimus trough levels in solid organ transplant recipients experiencing gastroenteritis.

Main Methods:

  • Tacrolimus trough levels were measured in six solid organ transplant recipients before, during, and after gastroenteritis.
  • Patients included kidney, kidney-pancreas, and liver transplant recipients.

Main Results:

  • All patients exhibited elevated tacrolimus trough levels (20-60 ng/ml) during gastroenteritis.
  • Tacrolimus levels returned to the therapeutic range after gastroenteritis resolved with symptomatic therapy and dose adjustment.

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Conclusions:

  • Gastroenteritis can lead to increased tacrolimus levels in solid organ transplant recipients.
  • Close monitoring of tacrolimus levels during diarrhea is recommended to prevent intoxication.