Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hypothalamic magnocellular neurosecretory system in developing rats.

E F Lipari1, D Lipari, A Gerbino

  • 1Dipartimento di Medicina Sperimentale, Università di Palermo. luana.lipari@tiscalinet.it

European Journal of Histochemistry : EJH
|August 22, 2001
PubMed
Summary

The magnocellular system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BEAGLE 2.0: A Web Server for RNA Secondary Structure Similarity Detection Leveraging SHAPE-directed RNA Structure Determination.

Journal of molecular biology·2025
Same author

Editorial: Ageing and physical activity: a multidimensional approach with new technology.

Frontiers in sports and active living·2025
Same author

Human neural stem cells derived from fetal human brain communicate with each other and rescue ischemic neuronal cells through tunneling nanotubes.

Cell death & disease·2024
Same author

Current status and future perspectives in HER2 positive advanced gastric cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2022
Same author

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.

GeroScience·2020
Same author

Critical analysis of major and ancillary features of LI-RADS v2018 in the differentiation of small (≤ 2 cm) hepatocellular carcinoma from dysplastic nodules with gadobenate dimeglumine-enhanced magnetic resonance imaging.

European review for medical and pharmacological sciences·2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Endocrinology

Background:

  • Limited research exists on the developmental trajectory of the magnocellular system.
  • Existing studies present conflicting data regarding the ontogeny of magnocellular neurosecretory cells.

Purpose of the Study:

  • To investigate the developmental timeline of vasopressin and oxytocin synthesis in the rat magnocellular system.
  • To determine the onset of neurosecretory activity in hypothalamic nuclei during development.

Main Methods:

  • Immunohistochemistry using antivasopressin and antioxytocin antibodies in developing rats.
  • Reverse transcription-polymerase chain reaction (RT-PCR) to detect hormone synthesis and neurosecretory activity.

Main Results:

Related Experiment Videos

  • Supraoptic nuclei emerge on day 16 of intrauterine life; paraventricular nuclei emerge on day 18.
  • Both nuclei initiate vasopressin neurohormone synthesis immediately upon appearance.
  • Oxytocin synthesis begins on postnatal day 2, potentially linked to decreasing placental oxytocin.

Conclusions:

  • Establishes a clear developmental sequence for vasopressin and oxytocin synthesis in the rat magnocellular system.
  • Provides critical data on the timing of neurosecretory cell maturation and hormone production.
  • Suggests a potential regulatory role of maternal placental oxytocin in the onset of fetal oxytocin synthesis.