Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Precipitated withdrawal following codeine administration is dependent on CYP genotype.

M Chew1, J M White, A A Somogyi

  • 1Department of Clinical and Experimental Pharmacology, Adelaide University, 5005, Adelaide, Australia.

European Journal of Pharmacology
|August 22, 2001
PubMed
Summary

Metabolic polymorphism influences codeine dependence. Codeine bioconversion to morphine is critical for physical dependence and withdrawal symptoms, like hypothermia, in rats.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with persistent opioid use 6-12 months after primary total knee arthroplasty.

Anaesthesia·2022
Same author

Persistent postoperative pain after total knee arthroplasty: a prospective cohort study of potential risk factors.

British journal of anaesthesia·2018
Same author

Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression.

Acta psychiatrica Scandinavica·2016
Same author

Pharmacogenetics of opioid response.

Clinical pharmacology and therapeutics·2015
Same author

Opioid activation of toll-like receptor 4 contributes to drug reinforcement.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2012
Same author

Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells.

British journal of cancer·2012

Area of Science:

  • Pharmacology
  • Toxicology
  • Genetics

Background:

  • Metabolic polymorphism, particularly in cytochrome P450 enzymes, can significantly alter drug efficacy and toxicity.
  • Understanding these metabolic pathways is crucial for predicting drug response and dependence liability.

Purpose of the Study:

  • To investigate the role of metabolic polymorphism in the development of physical dependence on codeine.
  • To compare codeine and morphine withdrawal severity in rats with differing cytochrome P450 2D2 (CYP2D2) activity.

Main Methods:

  • Utilized Dark Agouti (CYP2D2 deficient) and Sprague-Dawley (CYP2D2 intact) rats.
  • Assessed naloxone-precipitated withdrawal severity after codeine and morphine administration.
  • Measured plasma morphine concentrations and monitored hypothermia and body weight loss.

Related Experiment Videos

Main Results:

  • Sprague-Dawley rats exhibited significantly higher plasma morphine concentrations after codeine administration compared to Dark Agouti rats.
  • Codeine withdrawal induced significantly greater hypothermia in Sprague-Dawley rats.
  • A clear relationship was established between plasma morphine concentration and body temperature during withdrawal.

Conclusions:

  • Codeine dependence and withdrawal are critically dependent on its metabolic conversion to morphine.
  • CYP2D2 activity plays a significant role in modulating the pharmacological effects and dependence potential of codeine.