Related Experiment Videos
Malignant meningioma metastasizing through the cerebrospinal pathways
Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1975
Abstract:
A 53-year old man presented with a malignant meningioma which was incompletely removed. The tumour subsequently metastasized through the cerebrospinal pathways causing clinical signs through invasion of the cranial nerve roots. Microscopically, the metastatic deposits displayed a papillary pattern and increased anaplastic cytological features.
Insights
A malignant meningioma recurred and spread via cerebrospinal fluid pathways, invading cranial nerves. Microscopic analysis revealed papillary patterns and increased anaplastic features in metastatic deposits.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Malignant meningiomas are rare primary brain tumors.
- Incomplete resection is a risk factor for tumor recurrence and metastasis.
- Cerebrospinal fluid (CSF) dissemination is an uncommon but aggressive pattern of spread.
Purpose of the Study:
- To report a case of malignant meningioma with extensive cerebrospinal fluid metastasis.
- To highlight the histopathological features of metastatic meningioma.
- To discuss the clinical implications of CSF spread in meningioma.
Main Methods:
- Case presentation of a 53-year-old male patient.
- Review of surgical and histopathological findings.
- Analysis of tumor spread along cerebrospinal pathways.
Main Results:
- Incomplete removal of the initial malignant meningioma.
- Metastasis of the tumor through cerebrospinal pathways.
- Clinical signs due to cranial nerve root invasion.
- Microscopic identification of papillary pattern and increased anaplastic cytological features in metastatic deposits.
Conclusions:
- Malignant meningioma can metastasize via CSF pathways despite initial treatment.
- Papillary pattern and high-grade cytology indicate aggressive behavior.
- Early detection and aggressive management are crucial for patients with metastatic meningioma.