Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biflavonoids as novel antituberculosis agents.

Y M Lin1, M T Flavin, C S Cassidy

  • 1MediChem Life Sciences, Woodridge, IL 60517, USA. ylin@medichem.com

Bioorganic & Medicinal Chemistry Letters
|August 22, 2001
PubMed
Summary

Biflavonoids show promise as a new class of antituberculosis agents. Several compounds effectively inhibited Mycobacterium tuberculosis (Mtb) growth in laboratory tests, suggesting potential for new drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between antiretroviral therapy effectiveness and major chronic diseases and death among HIV-infected patients in Taizhou, Zhejiang Province, 1998-2023].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Optimal duration of preoperative imatinib therapy in locally advanced gastrointestinal stromal tumors].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2025
Same author

Artificial superconducting Kondo lattice in a van der Waals heterostructure.

Nature communications·2024
Same author

[Prognostic value and imaging features of (18)F-FDG PET-CT in follicular lymphoma with different histopathology grade].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2024
Same author

[Screen viewing in children under 3 years old: a review of correlates based on socio-ecological models].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2023
Same author

Benralizumab: A novel treatment for the cutaneous features of paediatric eosinophilic granulomatosis with polyangiitis (pEGPA).

The Australasian journal of dermatology·2023

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Microbiology

Background:

  • Tuberculosis (TB) remains a significant global health challenge, driven by the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb).
  • There is an urgent need for novel therapeutic agents with unique mechanisms of action to combat Mtb infections.

Purpose of the Study:

  • To investigate the potential of biflavonoids, a class of natural and synthetic compounds, as inhibitors of Mycobacterium tuberculosis growth.
  • To identify specific structural features of biflavonoids that contribute to antitubercular activity.

Main Methods:

  • A library of naturally occurring and synthetic biflavonoids was screened for inhibitory activity against the Mtb H37Rv strain.
  • Inhibition percentages were determined at a standard screening concentration of 12.5 microg/mL.

Related Experiment Videos

Main Results:

  • Compounds 6, 24, and 25 exhibited significant inhibitory activity, with 96%, 95%, and 87% inhibition, respectively.
  • The study suggests that the linkage type and the presence of methoxy- and nitro-substituents on the biflavonoid structure may influence their antimycobacterial efficacy.

Conclusions:

  • Biflavonoids represent a promising new class of compounds with potential as antituberculosis agents.
  • Further research into biflavonoid derivatives could lead to the development of novel drugs against Mtb infections.